Animal Control is back in operation under the leadership of Doctor Vargas and Doctor Mars. This time they are determined to destroy every shifter in North America.
Doctor Mars has recovered the genome for the strain of Ebola that late Moose spliced to target shifters and the occasional household pet. Mars has concluded that household pets are acceptable collateral damage if he can fulfill the mission assigned him by Vargas. She wants every werewolf in the country bled out and paws up as soon as possible.
A new lab has been established stocked with men, women and children shifters from raided werewolf sanctuaries. Mars is running out of werewolf lab rats, Vargas is pressuring him to do more.
Yoda and Bone recall Leon and Samantha to the fight. This time the stakes are higher than ever. The entire race of shifters is under threat. Yoda digs deep, the Haitian Loa of death is summoned and bargains are made.